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Scientific Papers

AYURVEDA

1. Ayurveda and I (Farewell Speech) The Dhanvantari, Madras. 3:18-19 (Sept. 22 and Oct. 8, 1923)

2. Shleepadamu (Filariasis). The Dhanvantari, Madras. 3 (1923): 26-30, 52-57, 85-86 and 117-119. (in Telugu)

3. Hysteria. The Dhanvantari, Madras. 3 (1923): 58-61 and 74-75 (in Telugu)

4. Vayu leka Vatamu. The Dhanvantari, Madras. 3 (1923):147-149 (in Telugu)

5. Vayu or Vata. Andhra Medical Journal, Madras 2:1-3. February1924

6. Origin of Hindu Medicine III: Panchamahabhutas. Swarajya Daily, Madras (192?)

7. Hindu Pharmacology Vol I (Manuscript, December 1922)

PHOSPHORUS

8. The colorimetric determination of phosphorus. (with C.H. Fiske) Journal of Biological Chemistry 66 (1925):375-400

PHOSPHOCREATINE AND ATP

9. The "inorganic phosphate" of muscle. (with C.H. Fiske) Journal of Biological Chemistry 74 (1927): xxii (an abstract)

10. The nature of the "inorganic phosphate" in voluntary muscle. (with C.H. Fiske) Science 65:401-403. April 22, 1927

11. The isolation and function of Phosphocreatine. (with C.H. Fiske) Science 67:169-170. February10, 1928

12. Phosphocreatine. (with C.H. Fiske) Journal of Biological Chemistry 81 (1929):629-679

13. Phosphorus compounds of muscle and liver. (with C.H. Fiske) Science 70:381-382. October 18, 1929

THE ANTI-PERNICIOUS ANAEMIA FACTOR (Vitamin B12)

14. The multiple nature of the pernicious anemia principle in liver. (with C.H. Fiske and B.M. Jacobson) Journal of Clinical Investigation 14 (1935):709 (an abstract)

15. The separation of the substances in liver which are reticulocytogenic in the guinea-pig and which are therapeutically effective in experimental canine black tongue. (with B.M. Jacobson and C.H. Fiske) New England Journal of Medicine 212:663-664. April 11, 1935

16. Chemical studies of pernicious anemia principle in liver. (with B.M. Jacobson) Journal of Biological Chemistry 114 (1936): cii-ciii

17. A partially purified liver extract therapeutically effective in pernicious anemia. (with B.M. Jacobson and C.H . Fiske) New England Journal of Medicine 214:194.January 30, 1936

18. Studies of the pernicious anemia principle in liver. III. The isolation and properties of a substance with primary therapeutic activity. (with B.M. Jacobson and V. Prochownick) Journal of the American Chemical Society 58 (1936):2234-2236

19. Studies of principle in liver effective in pernicious anemia. IV. Therapeutic activity of its multiple factors. (with B.M. Jacobson) Journal of Clinical Investigation 16 (1937):573-585

20. Studies of the principle in liver effective in pernicious anemia. V. Additional accessory factors and further properties of the primary factor. (with B.M. Jacobson and S.J. Hartfall) Journal of Clinical Investigation 17 (1938):517 (an abstract)

21. Studies of the principle in liver effective in pernicious anemia. (with B.M. Jacobson) Journal of American Medical Association 116:367-373. February 1, 1941

22. The chemistry of the anti-pernicious anemia substances of liver. Current Science, India 11(1942):311-324

23.Chemistry of anti-pernicious anemia substances of liver. (with A.B. Hastings and Milton Elkin) Vitamins & Hormones 3 (1945):237-296

PELLAGRA AND NIACIN

24. The separation of the substances in liver which are reticulocytogenic in the guinea pig and which are therapeutically effective in experimental canine black tongue. (with B.M. Jacobson and C.H. Fiske) New England Journal of Medicine 212:663-664. Apr 11, 1935 (same as 15)

25. Modern views on pellagra. (with W.J. Dann) British Medical Journal 1:809-812. April 9, 1938

26. Differentiation of the rat dermatitis factor and the chick dermatitis factor from nicotinic acid. (with W.J. Dann) Journal of Nutrition 16.(1938):183-195

27. The effect of beta-aminopyridine in experimental blacktongue. (with W.J. Dann and E. Meilman) Journal of the American Chemical Society 60 (1938):1510-1511

28. Inactivity of beta-aminopyridine in blacktongue (with W.J. Dann) Journal of the American Chemical Society 60 (1938):2565

PANTOTHENIC ACID

29. Studies on the nutritional requirements of hemolytic streptococci. I. Effect of various substances isolated from liver extract on hemolytic streptococci. (with Leo Rane) Proceedings of the Society of Experimental Biology and Medicine 38 (1938): 837-839

30. Pantothenic acid as a growth factor for the Dochez N.Y, 5 strain of hemolytic streptococcus. (with Leo Rane) Journal of the American Chemical Society 61 (1939):1616

31. Rat growth factors of filtrate fraction of liver extracts. (with G.H. Hitchings) Journal of Nutrition 18 (1939):265-276

32. Pantothenic acid as a factor in rat nutrition (with G.H. Hitchings) Journal of the American Chemical Society 61 (1939):1615-1616 .

BIOTIN

33. Studies on cultural requirements of bacteria: Tissue extractives in growth of diphtheria bacillus. (with J.H. Mueller) Journal of Bacteriology 34 (1937):153-161

34. Experiments on the antidermatitis component of the filtrate factor in rats (with Paul Gyorgy and C.E. Poling) Proceedings of the Society of Experimental Biology and Medicine 42 (1939): 738-740

35. The factor curative of nutritional achromotrichia. (with Paul Gyorgy and C.E. Poling) Journal of Biological Chemistry 132 (1940):789-90

36. Biotin IV. A second synthesis of 2-(delta-carboxybutyl)-thiophane-3,4-dicarboxylic acid. (with B.R. Baker, M.V. Querry, S. Bernstein and S.R. Safir) Journal of Organic Chemistry 12 (1947):167-173

37. Biotin. VI. Synthesis of biotin and epi-allobiotin. (with B.R. Baker, M.V. Querry, W.L. McEwen, S. Bernstein, S.R. Safir and L. Dorfman) Journal of Organic Chemistry 12 (1947): 186-198

38. Biotin. IX. A synthesis of dl-dehydrobiotin. (with S.R. Safir, S. Bernstein, B.R. Baker and W.L. McEwen) Journal of Organic Chemistry 12 (1947):475-482

39. The requirement of biotin for the growth of pneumococci. (with N. Bohonos) Archives of Biochemistry 3 (1943): 257-259

MISCELLANEOUS B COMPLEX VITAMINS

40. A new bios factor in liver extract. (with B. Alexander) Journal of Biological Chemistry 135 (1940):341-342

41. Choline, pantothenic acid and nicotinic acid as essential growth factors for pneumococcus. (with Leo Rane) Journal of Biological Chemistry 134 (1940):455-456

42. Nutritional requirements of the pneumococcus. 1. Growth factors for types I, II, V, VII, VIII. (with Leo Rane) Journal of Bacteriology 40 (1940):695-704

43. The relation of pantothenic acid and succinic acid to the growth of certain micro-organisms. (with Leo Rane) Journal of Nutrition 21 (1941 Suppl): 17

44. A lactobacillus of cecal origin requiring oleic acid. (with A.R. Whitehill and J.J. Oleson) Archives of Biochemistry 15 (1947):31-37

45. The chemical nature of growth factors required by mosquito larvae. I. Riboflavin and thiamine. (with W. Trager). Biological Bulletin 75 (1938) 75-84

46. The chemical nature of growth factors required by mosquito larvae. 11. Pantothenic acid and vitamin B6. (with W. Trager) Journal of General Physiology 23 (1940): 561-568.

FOLIC ACID

47. Synthesis of a compound identical with the L. casei factor isolated from liver. (Angier, Boothe, Hutchings, Mowat, Semb, Stokstad, SubbaRow, Waller, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith*) Science 102:227-228. August 31, 1945

48. The structure and synthesis of the liver L. casei factor. (Angier, Boothe, Hutchings, Mowat, Semb, Stokstad, SubbaRow, Waller, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith) Science 103:667-669. May 31, 1946

Papers to New York Academy of Sciences Conference on May 23, 1946:

49. Isolation of the Liver L. casei Factor (Stokstad, Hutchings and SubbaRow) Annals of the New York Academy of Sciences 48 (1946):261-263

50. Isolation of the Fermentation L.casei Factor (Hutchings, Stokstad, Bohonos, Sloane and SubbaRow) Ibid. 265-267

51. Degradation of the Fermentation L. casei Factor. I. (Stokstad, Hutchings, Mowat, Boothe, Waller, Angier, Semb and SubbaRow) Ibid. 269-273. II. (Hutchings, Stokstad, Mowat, Boothe, Waller, Angier, Semb and SubbaRow) Ibid. 273-277

52. Structure and synthesis of the pteridine degradation products of the Fermentation L casei Factor. (Mowat, Boothe, Hutchings, Stokstad, Waller, Angier, Semb, Cosulich and SubbaRow) Ibid. 279-81

53. Synthesis of pteroylglutamic acid (Liver L. casei factor) and pteroic acid. (Waller, Hutchings, Mowat, Stokstad, Boothe, Angier, Semb, SubbaRow, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith) Ibid. 283-287

54. Synthesis of pteroylglutamic acid (Liver L. casei Factor) and pteroic acid. II. (Hultquist, Kuh, Cosulich, Fahrenbach, Northey, Seeger, Sickels, Smith, Angier, Boothe, Hutchings, Mowat, Semb, Stokstad, SubbaRow and Waller) Ibid. 48 Suppl. (1947) I-VI

55. A chemical method for the determination of pteroylglutamic acid and related compounds. (Hutchings, Stokstad, Boothe, Mowat, Waller, Angier, Semb and SubbaRow) Journal of Biological Chemistry 168 (1947):705-710

More informative contributions to the Journal of the American Chemical Society:

56. The isolation of the Fermentation Lactobacillus casei Factor. (Hutchings, Stokstad, Bohonos, Sloane and SubbaRow) JACS 70 (1948): 1-3

57. The isolation of the Lactobacillus casei Factor from liver (Stokstad, Hutchings and SubbaRow) Ibid:3-5

58. The degradation of the Fermentation L. casei Factor. I. (Stokstad, Hutchings, Mowat, Boothe, Waller, Angier, Semb and SubbaRow) Ibid: 5-9

59. Degradation of the Fermentation L. casei Factor. II. (Hutchings, Stokstad, Mowat, Boothe, Waller, Angier, Semb and SubbaRow) Ibid :10-13

60. The structure of the Liver L. casei Factor. (Mowat, Boothe, Hutchings, Stokstad, Waller, Angier, Semb, Cosulich and SubbaRow). Ibid :14-18

61. Synthesis of pteroylglutamic acid (Liver L. casei Factor) and pteroic acid. I. (Waller, Hutchings, Mowat, Stokstad, Boothe, Angier, Semb, SubbaRow, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith) Ibid :19-22

62. Synthesis of pteroylglutamic acid (Liver L. casei Factor) and pteroic acid. II. (Hultquist, Kuh, Cosulich, Fahrenbach, Northey, Seeger, Sickels, Smith, Angier, Boothe, Hutchings, Mowat, Semb, Stokstad SubbaRow and Waller) Ibid :23-24

63. Synthesis of pteroylglutamic acid. III. (Angier, Stokstad, Mowat, Hutchings, Boothe, Waller, Semb, SubbaRow, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith) Ibid: 25-26

64. Synthesis of pteroylglutamic acid. IV. (Boothe, Waller, Stokstad, Hutchings, Mowat, Angier, Semb, SubbaRow, Cosulich, Fahrenbach, Hultquist, Kuh, Northey, Seeger, Sickels and Smith) Ibid :27-28

65. The preparation of 2-amino-4-hydroxy-6-keto-5,5-dichlorodihydropyramidine. (Angier, Mowat, Boothe, Waller, Semb, Hutchings, Stokstand and SubbaRow) Ibid: 1274-1275

66. Pteridine chemistry. I. (Angier, Waller, Boothe. Mowat, Semb, Hutchings, Stokstad and SubbaRow) Ibid :3029-3031

( *Folic Acid scientists: Lederle Laboratories: Drs. Robert B. Angier, Nestor Bohonos, James H. Boothe, Brian L. Hutchings, John H. Mowat, Joseph Semb, Nathan Sloane, E.L.R. Stokstad, Y. SubbaRow and Coy W. Waller. Calco Chemical Division of American Cyanamid Company: Drs. Donna B. Cosulich, Marvin J. Fahrenbach, Martin E. Hultquist, Erwin Kuh, Elmore H. Northey, Doris R. Seeger, Jackson P. Sickels and James M. Smith, Jr.)

CANCER DRUGS

67. Pteroylaspartic acid, an antagonist for pteroylglutamic acid. (Hutchings, Mowat, J.J. Oleson, Stokstad, Boothe, Waller, Angier, Semb and SubbaRow) Journal of Biological Chemistry 170 (1947):323-328

68. Pteroic acid derivatives. I. Pteroyl-alpha-glutamylglutamic acid and pteroyl-alpha, gamma-glutamyl-diglutamic acid. (Mowat, Hutchings, Angier, Stokstad, Boothe, Waller, Semb and SubbaRow) Journal of American Chemical Society 70 (1948):1096-1098

69. Pteroic acid derivatives. II. Pteroyl-gamma-glutamylglutamic acid and pteroyl-gamma-glutamyl-gamma~glutamylglutamic acid. (Boothe, Mowat, Hutchings, Angier, Waller, Stokstad, Semb, A.L. Gazzola, and SubbaRow) Ibid :1099-1102

70. Pteroic acid derivatives. III. Pteroyl-gamma-glutamylglutamic acid and pteroyl-gamma-glutamyl-gamma-glutamylglutamic acid. (Boothe, Semb, Waller, Angier, Mowat, Hutchings, Stokstad and SubbaRow) Ibid: 71 (1949):2304-2308

71. Pteroic acid derivatives. IV. Pteroyl-alpha, gamma-glutamyldiglutamic acid. (Mowat, A.L. Gazzola, Hutchings, Boothe, Waller, Angier, Semb and SubbaRow) Ibid:2308-10

72. Pteroic acid derivatives. V. Pteroyl-alpha-glutamyl-alpha-glutamylglutamic acid, pteroyl-gamma-glutamyl-alpha-glutamylglutamic acid and pteroyl-alpha-glutamyl-gamma- glutamylglutamic acid. (Semb, Boothe, Angier, Waller, Mowat, Hutchings and SubbaRow) Ibid:2310-2315

73. Pteroic acid derivatives. VI. Unequivocal syntheses of some isomeric glutamic acid peptides. (Angier, Waller, Hutchings, Boothe, Mowat, Semb and SubbaRow) Ibid: 72 (1950):74-77

74. Synthesis of pteroyl-gamma-glutamyl-gamma-glutamylglutamic acid (teropterin). (Boothe, Mowat, Hutchings, Angier, Waller, Stokstad, Semb, A.L. Gazzola and SubbaRow) Transactions of the New York Academy of Sciences. Series II 10 (Jan. 1948): 70-71

75. The effect of folic acid and its antagonists on Rous chicken sarcoma. (with Paul Little, A. Sampath, V. Paganelli, and E. Locke) Ibid: 91-98

76. Effect of nutrition on tumor response in Rous chicken sarcoma. (with Paul Little and J.J. Oleson) Journal of Laboratory and Clinical Medicine 33 (1948):1139-1143

77. Use of antagonists of pteroylglutamic acid in controlling Rous chicken sarcoma. (with Paul Little and A.Sampath) Ibid: 1144-1149

78. Synthesis and some biological properties of 4-aminopteroylaspartic acid. (Hutchings, Mowat, J.J. Oleson, A.L. Gazzola, E.M. Boggiano, Seeger, Boothe, Waller, Angier, Semb and SubbaRow) Journal of Biological Chemistry 180 (1949):857-863

79. Studies on the inhibitory nature of 4-aminopteroylglutamic acid. (with J.J. Oleson and B.L. Hutchings) Ibid : 175 (1948): 359-365

80. Growth inhibition by substances in liver. (with A.M. Brues, E.B. Jackson and J.C. Aub) Journal of Experimental Medicine 71 (1940):423-438

HETRAZAN

81. Experimental chemotherapy of filariasis. I. Experimental methods for testing drugs against naturally acquired filarial infections in cotton rats and dogs. (with R.I. Hewitt, W.S. Wallace, and E. White) Journal of Laboratory and Clinical Medicine 32 (1947):1293-1303

82. Experimental chemotherapy of filariasis. II. Effect of piperazine derivatives against naturally acquired filarial infections in cotton rats and dogs. (with R.I. Hewitt, E. White, W.S. Wallace, H.W. Stewart an d S. Kushner) Ibid : 1304-1313

83. Experimental chemotherapy of filariasis. III. Effect of 1-diethyl-carbamyl-4-methylpiperazine hydrochloride against naturally acquired filarial infections in cotton rats and dogs. (with R.I. Hewitt, S. Kushner, H.W. Stewart, E. White and W.S. Wallace) Ibid:1314-1329

84. Experimental chemotherapy of filariasis. IV. The preparation of derivatives of piperazine. (with H.W. Stewart, R.J. Turner, J.J. Denton, S. Kushner, L.M. Brancone, W.L. McEwen, and R.I. Hewitt) Journal of Organic Chemistry 13 (1948):134-143

85. Experimental chemotherapy of filariasis. V. The preparation of derivatives of piperazine. (with S. Kushner, L.M. Brancone, R.I. Hewitt, W.L. McEwen, H.W. Stewart, R.J. Turner and J.J. Denton) Ibid: 13 (1948):144-153

86. Studies on the chemotherapy of filariasis. VI. Some pharmaco-dynamic properties of 1-diethylcarbamyl-4-methylpiperazine hydrochloride, Hetrazan. (with B.K. Harned, Raymond W. Cunningham, Sybella Halliday, R.E. Vessey, N.N. Yuda, Mary C. Clark, Carolyn H. Hine and Rachel Cosgrove) Journal of Laboratory and Clinical Medicine 33 (1948):216-235

87. The treatment of ascariasis in dogs with 1-diethylcarbamyl-4-methyl-piperazine hydrochloride. (with R. Hewitt, W. Wallace and E. White) Journal of Parasitology 34 (1948):237-239

98. The chemistry of piperazine compounds in the chemotherapy of filariasis. (with S. Kushner, L.M. Brancone, R.I. Hewitt, W.L. McEwen, H.W. Stewart, R.J. Turner and J.J. Denton) Annals of the New York Academy of Sciences 50 (1948):120-127

89. Parasitology of piperazines in the treatment of filariasis. (with R.I. Hewitt, D.E. White, S. Kushner, W.S. Wallace, and H.W. Stewart) Ibid :128-140

90. Some toxicological and pharmacological properties of 1-diethylcarbamyl-4-methylpiperazine hydrochloride, Hetrazan (with B.K. Harned, R.W. Cunningham, Sybella Halliday, R.E. Vessey, N.N. Yuda and Mary C. Clark) Ibid :141-160

POLYMYXIN

91. Chemical studies of polymyxin: Comparison with "Aerosporin" (with P.H. Bell et al of Stamford; and A.C. Dornbush. and S. Kushner of Lederle) Annals of the New York Academy of Sciences 51 (1949):897-908

AUREOMYCIN

92. The Pharmacology of Duomycin. (with B.K. Harned, R.W. Cun�ningharn, M.C. Clark, R. Cosgrove, C.H. Hine, W.J. McCauley, E. Stokey, R.E. Vessey and N.N. Yuda) Annals of the New York Academy of Sciences 51 (1948):182-210

DARVISUL

93. An effective antiviral synthetic. (with M. Sanders and R.C. Alexander) Texas Reports on Biology and Medicine 6 (1948):385-395

94. N-heterocyclic benzene sulfonamides. (with Martin E. Hultquist, Richard P. Germann, John S. Webb, William B. Wright Jr. Barbara Roth and James M. Smith Jr.) Journal of the American Chemical Society 73 (1951):2558-2566

95. U.S. Patent Office, 2,525,319 : Hydroxysulfonamidothiazoles and preparation of the same. (with Martin E. Hultquist)

96. U.S. Patent Office 2,535,635 . Substituted pyrimidines and preparation of the same. (with Martin E. Hultquist)

97. The Patent Office, London 662,798 : Improvements in or relation to the production of Sulphonamides and Intermediates thereof. (with Martin E. Hultquist)

STEROIDS

98. Steroids and the stiffness syndrome in guinea pigs. (with J.J. Oleson, Evelyn C. Van Donk, S. Bernstein and Louis Dorfman) Journal of Biological Chemistry 171 (1947):1-7

99. 7-dehydrocholesteryl chloride and bromide (with S. Bernstein, K.J. Sax) Journal of Organic Chemistry 13 (1948):837-842

100. 7-dehydrocholesterol. (with S. Bernstein, L.J. Binovi, L. Dorfrnan and K.J. Sax) Journal of Organic Chemistry 14 (1949):433-446

TUBERCULOSIS

101. Experimental chemotherapy of tuberculosis. I. Substituted nicotinamides. (with S. Kushner, Harry Dalalian, Robert T. Cassell,. J.L. Sanjurjo and D. McKenzie) Journal of Organic Chemistry 13 (1948):834-836

102. The effect of nicotinic acid amide on experimental tuberculosis of white mice (with D. McKenzie, L. Malone, S. Kushner, and J.J. Oleson) Journal of Laboratory and Clinical Medicine 33 (1948):1249-1253

TRYPANOSOMIASIS

103. Experimental chemotherapy of trypanosomiasis. I. Effect of p-phenylene diguanidine and related compounds against experimental infections with Trypanosoma equiperdum. (with R.I. Hewitt, A. Gumble, S. Kushner, S.R. Safir and, L.M. Brancone) Journal of Pharmacology and Experimental Therapeutics 96 (1949):305-314

104. Experimental chemotherapy of trypanosomiasis. II. The preparation of compounds related to p-phenylene diguanidine. (with S.R. Safir, S. Kushner and L.M. Brancone) Journal of Organic Chemistry 13 (1948):924-932

105. A practical liquid medium for cultivation of Trypanosoma cruzi in large volumes. (with Paul A. Little) Journal of Bacteriology 50 (1945):57-60

BLOOD PRESSURE

106. A new method for the indirect measurement of blood pressure in the rat. (with H. Kersten, W.G. Brosene Jr., and F. Ablondi) Journal