Some people like to tinker with gadgets.
They take apart and repair watches or spend all day in
the garage working on cars.
Biotechnologists tinker with living organisms. They
use biochemistry and genetics to create new products
for the agricultural, industrial, and. environmental
industries. These products include vaccines,
medicines, growth hormones for plants, and food
AREAS OF BIOTECHNOLOGY
culture and plant breeding
DNA or Gene
CHANGE - RELEVANCE
businesses hate change. People with great jobs hate
change. But upstarts and entrepreneurs love change.
There are always more competitors than market leaders,
and there's a huge demand for change.
More innovation! More competition! More change!
It won't go away...
CHANGE - THE CHALLENGE
We work for
companies that are organisms, living, breathing,
changing organisms that interact with millions of
other living, breathing, changing organisms. This is
not business as usual.
It's a new principle
that is going to feel unnatural at first. We will need
a new vocabulary just to discuss it.
REMEDY - THE EVOLUTION
Defined as inheritable modifications over many
generations, evolution is the most powerful tool we
have for dealing with change. Individuals and
organisations can put this organic process to use by
permitting change to occur.
DENYING EVOLUTION & IMPLICATIONS
The simple engine of evolution ... .inheritable
changes in the species occurring over thousands of
generations ... can produce extraordinary results.
Charles Darwin felt that people have trouble
visualizing anything that took place over the course
of a hundred million years. These days, in a world
where McDonald's aims to provide you with food in less
than 60 seconds, it may be even harder for people to
make the leap.
Research is now at
a turning point. Memetic evolution ... evolution
caused by memes, or ideas for units of innovation ...
is driving our research needs to change faster and
Penguins don't evolve on
purpose. They don't have meetings about evolution.
They don't debate the most effective routes for their
future on the island either. Instead, evolution is
built into their daily lives and embodied in their
reprodtive cycle. And because evolution is automatic,
it happens whether the penguins find time for it or
The difference between a
penguin and an organization is simple: While both have
evolved to a point where they can succeed, the penguin
continues to evolve whereas an organization usually
YOUR TEST - TO
CHANGE & EVOLVE Can you imagine these thoughts?
. Total vaccinations for all possible disease areas.
. Only few days cure regime for tuberculosis.
. Simplified treatment for the most complicated
. Vegetables to come from plants in
the peeled form as housewives do not like to have
trouble of peeling vegetables in the kitchen.
. Instead of grains, atta direct from plants.
Quality: Safe for humans and meets standards
Timeliness: Reproducible and First to
Quantity: Scalable and adequate
productivity to meet market demand.
Acceptable, predictable economies of scale.
Select clone, Cell banking and characterization.
Process development and QC methods development.
Prepare for Tox study. GMP manufacturing. CEO IND
What is the cost of being wrong?
Excess capacity: The estimated carrying cost of a
facility operating at 50% capacity is $ 2-3 Million a
month. Example: Synergen (Antril)
Inadequate capacity: A 50% shortage is estimated to
result in a 40-45 million dollar loss of operating
profit. Example: Immunex (Enbrel)
TOO MANY CONTIGUOUS ACTIVITIES
Timeliness . Assay
QA/QC . Phase I/II Clinical
Protocol . FDA
Previous Human Experience .
Investigator vs Sponsor IND
Sub contractors .
Manufacturing . Pre-IND Meetings
Orphan Drug Status . Record keeping
trial agreements . Fast Track
formulation . Drug vialing
Drug Stability . CMC
BIOTECH CAREER OPPORTUNITIES
the present employee strength of 50,000, the number of
jobs in the biotechnology sector is projected to
increase by 10 lakh by 2012.
Set to witness
an IT-like revolution in the country, this field is
now a hot career option for students. In fact, it is a
happening career destination.
* Production -
Model organisms in Drug Discovery & Development
* Research & Development
* Quality Control
* Quality Assurance
* Regulatory Affairs
* Intellectual Property Rights - Patents in Post
* Clinical Research
Sales & Marketing - Product Management, Market
Research, Training & Development, Sales
Administration, Distribution streamlining
Business Development - Domestic / International
* Financial Analyst
* Communication & Reporting - Specialization in
Biotechnology - India Today, Business Standard,
PANACEA BIOTEC AT A GLANCE
India's leading research-based Health Management
Company, Panacea Biotec is the second largest vaccine
producer, and amongst top 50 Pharmaceutical companies
It is ranked third amongst all
Biotechnologies companies in India by ABLE Survey,
One of the only four companies in the
world having WHO pre-qualification for the Oral Polio
Vaccine. It has10 Global Drug Delivery Product
Patents. It has established Brand Equity in Pediatric
Vaccines, Pain and Diabetes Management, and Organ
I t has manufacturing
facilities with WHO cGMP Certification, two
state-of-the-art R&D Centers with over 300 highly
Current Vaccine Portfolio
Poliomyelitis vaccine, live (oral)
Monovalent poliomyelitis vaccne type 1 live (oral )
. Monovalent poliomyelitis vaccine type 3 live (oral )
. Enivac HB Hepatitis B vaccine ( Recombinant )
. Enivac HB SAFSY - prefilled device Hepatitis B
Vaccine ( Recombinant )
. Evocac - 4 -
Combination vaccine - DPT + Hepatitis B
Easy Four - DPT + Hib
. Easy Five - DPT + Hep